Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing

Yanyu Xiong; Qinglan Huang; Taylor D. Canady; Priyash Barya; Shengyan Liu; Opeyemi H. Arogundade; Caitlin M. Race; Congnyu Che; Xiaojing Wang; Lifeng Zhou; Xing Wang; Manish Kohli; Andrew M. Smith; Brian T. Cunningham

doi:10.1038/s41467-022-32387-w

Nature Communications (Aug 2022)

Photonic crystal enhanced fluorescence emission and blinking suppression for single quantum dot digital resolution biosensing

Yanyu Xiong,
Qinglan Huang,
Taylor D. Canady,
Priyash Barya,
Shengyan Liu,
Opeyemi H. Arogundade,
Caitlin M. Race,
Congnyu Che,
Xiaojing Wang,
Lifeng Zhou,
Xing Wang,
Manish Kohli,
Andrew M. Smith,
Brian T. Cunningham

Affiliations

Yanyu Xiong: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign
Qinglan Huang: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign
Taylor D. Canady: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Priyash Barya: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign
Shengyan Liu: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign
Opeyemi H. Arogundade: Department of Bioengineering, University of Illinois at Urbana-Champaign
Caitlin M. Race: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign
Congnyu Che: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Xiaojing Wang: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Lifeng Zhou: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Xing Wang: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Manish Kohli: Department of Oncology, Huntsman Cancer Institute
Andrew M. Smith: Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana−Champaign
Brian T. Cunningham: Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign

DOI: https://doi.org/10.1038/s41467-022-32387-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Nanoscale emitters are useful for measuring biomolecular interactions, but are limited by weak signals. Here, the authors use a photonic crystal surface for 3000-fold signal enhancement, achieving single emitter sensitivity with extended on-time, and demonstrate its application in miRNA biomarker sensing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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