Manipulating Diastereomeric Bicyclononynes to Sensitively Determine Enzyme Activity and Facilitate Macromolecule Conjugations

• Chien-Hui Huang,
• Sin-Yu Hou,
• Scott Severance,
• Chi-Ching Hwang,
• Bo-Kai Fang,
• Ming-Mao Gong,
• Siao-Lei Yu,
• Yung-Chieh Weng,
• Li-Fang Wang,
• Chia-Yen Dai,
• Su-Hung Wang,
• Hsing-Tao Kuo,
• Jeh-Jeng Wang,
• Tzu-Pin Wang

Affiliations

Chien-Hui Huang

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Sin-Yu Hou

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Scott Severance

Department of Molecular and Cellular Sciences, Liberty University College of Osteopathic Medicine, Lynchburg, Virginia, United States

Chi-Ching Hwang

⊥Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Bo-Kai Fang

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Ming-Mao Gong

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Siao-Lei Yu

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Yung-Chieh Weng

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Li-Fang Wang

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Chia-Yen Dai

△School of Medicine and Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung, Taiwan

Su-Hung Wang

Division of Hepato-Gastroenterology, Department of Internal Medicine, Chi Mei Hospital, Tainan, Taiwan

Hsing-Tao Kuo

Division of Hepato-Gastroenterology, Department of Internal Medicine, Chi Mei Hospital, Tainan, Taiwan

Jeh-Jeng Wang

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

Tzu-Pin Wang

†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan