Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Iria Fernandez Botana; Giulia Pagano; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2023.2276490

OncoImmunology (Dec 2023)

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Iria Fernandez Botana,
Giulia Pagano,
Etienne Moussay,
Jerome Paggetti

Affiliations

Iria Fernandez Botana: Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg
Giulia Pagano: Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg
Etienne Moussay: Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg
Jerome Paggetti: Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg

DOI: https://doi.org/10.1080/2162402X.2023.2276490
Journal volume & issue: Vol. 12, no. 1

Abstract

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ABSTRACTChronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Published in OncoImmunology

ISSN: 2162-402X (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.tandfonline.com/journals/koni

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Abstract

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