The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice
Dániel Kuti,
Zsuzsanna Winkler,
Krisztina Horváth,
Balázs Juhász,
Anett Szilvásy-Szabó,
Csaba Fekete,
Szilamér Ferenczi,
Krisztina J. Kovács
Affiliations
Dániel Kuti
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary
Zsuzsanna Winkler
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary
Krisztina Horváth
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, 1083 Budapest, Hungary
Balázs Juhász
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, 1083 Budapest, Hungary
Anett Szilvásy-Szabó
Laboratory of Integrative Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, 1083 Budapest, Hungary
Csaba Fekete
Laboratory of Integrative Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, 1083 Budapest, Hungary
Szilamér Ferenczi
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary
Krisztina J. Kovács
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u 43, 1083 Budapest, Hungary; Corresponding author
Summary: There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked anxiety. Our data highlight differences in metabolic responses to acute- repeated- and chronic stressors, which might affect coping behavior and underlie stress-induced metabolic and psychopathologies.
