Nature Communications (Feb 2017)

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

  • Olga Barca-Mayo,
  • Meritxell Pons-Espinal,
  • Philipp Follert,
  • Andrea Armirotti,
  • Luca Berdondini,
  • Davide De Pietri Tonelli

Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14


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Core clock genes, such asBmal1, are expressed in astrocytes, but their contribution to the timekeeping system is unknown. Barca-Mayo et al. report that deletion of Bmal1in Glast+ astrocytes alters the neuronal clock through GABA signalling, leading to abnormal circadian locomotor behaviour and impaired cognition in mice.