Nature Communications (May 2017)
TNFα drives mitochondrial stress in POMC neurons in obesity
- Chun-Xia Yi,
- Marc Walter,
- Yuanqing Gao,
- Soledad Pitra,
- Beata Legutko,
- Stefanie Kälin,
- Clarita Layritz,
- Cristina García-Cáceres,
- Maximilian Bielohuby,
- Martin Bidlingmaier,
- Stephen C. Woods,
- Alexander Ghanem,
- Karl-Klaus Conzelmann,
- Javier E. Stern,
- Martin Jastroch,
- Matthias H. Tschöp
Affiliations
- Chun-Xia Yi
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Marc Walter
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Yuanqing Gao
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Soledad Pitra
- Department of Physiology, Augusta University
- Beata Legutko
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Stefanie Kälin
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Clarita Layritz
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Cristina García-Cáceres
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Maximilian Bielohuby
- Endocrine Research Unit, Klinikum der Ludwig-Maximilians-Universität
- Martin Bidlingmaier
- Endocrine Research Unit, Klinikum der Ludwig-Maximilians-Universität
- Stephen C. Woods
- Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati
- Alexander Ghanem
- Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität
- Karl-Klaus Conzelmann
- Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität
- Javier E. Stern
- Department of Physiology, Augusta University
- Martin Jastroch
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- Matthias H. Tschöp
- Division of Metabolic Diseases, Department of Medicine, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Technische Universität München, German Center for Diabetes Research (DZD)
- DOI
- https://doi.org/10.1038/ncomms15143
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Long-term consumption of a calorie-rich diet persistently activates brain microglia. Here, the authors show that microglial activity in mouse brains oscillates daily in conjunction with feeding, and that TNFα, secreted by activated microglia, induces mitochondrial stress in satiety-promoting POMC neurons.
