Nature Communications (Jul 2021)

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

  • Min Zhang,
  • Chengqi Wang,
  • Jenna Oberstaller,
  • Phaedra Thomas,
  • Thomas D. Otto,
  • Debora Casandra,
  • Sandhya Boyapalle,
  • Swamy R. Adapa,
  • Shulin Xu,
  • Katrina Button-Simons,
  • Matthew Mayho,
  • Julian C. Rayner,
  • Michael T. Ferdig,
  • Rays H. Y. Jiang,
  • John H. Adams

DOI
https://doi.org/10.1038/s41467-021-24814-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.