Nature Communications (Jul 2021)
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
- Min Zhang,
- Chengqi Wang,
- Jenna Oberstaller,
- Phaedra Thomas,
- Thomas D. Otto,
- Debora Casandra,
- Sandhya Boyapalle,
- Swamy R. Adapa,
- Shulin Xu,
- Katrina Button-Simons,
- Matthew Mayho,
- Julian C. Rayner,
- Michael T. Ferdig,
- Rays H. Y. Jiang,
- John H. Adams
Affiliations
- Min Zhang
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Chengqi Wang
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Jenna Oberstaller
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Phaedra Thomas
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Thomas D. Otto
- Wellcome Sanger Institute, Wellcome Genome Campus
- Debora Casandra
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Sandhya Boyapalle
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Swamy R. Adapa
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Shulin Xu
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- Katrina Button-Simons
- Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame
- Matthew Mayho
- Wellcome Sanger Institute, Wellcome Genome Campus
- Julian C. Rayner
- Wellcome Sanger Institute, Wellcome Genome Campus
- Michael T. Ferdig
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus
- Rays H. Y. Jiang
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- John H. Adams
- Center for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Florida
- DOI
- https://doi.org/10.1038/s41467-021-24814-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing features with artemisinin resistance.
