Nature Communications (May 2017)
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
- Chenhui Wang,
- Cun-Jin Zhang,
- Bradley N. Martin,
- Katarzyna Bulek,
- Zizhen Kang,
- Junjie Zhao,
- Guanglin Bian,
- Julie A. Carman,
- Ji Gao,
- Ashok Dongre,
- Haibo Xue,
- Stephen D. Miller,
- Youcun Qian,
- Dolores Hambardzumyan,
- Tom Hamilton,
- Richard M. Ransohoff,
- Xiaoxia Li
Affiliations
- Chenhui Wang
- Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
- Cun-Jin Zhang
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Bradley N. Martin
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Katarzyna Bulek
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Zizhen Kang
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Junjie Zhao
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Guanglin Bian
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Julie A. Carman
- Discovery Biology, Bristol-Myers Squibb
- Ji Gao
- Discovery Biology, Bristol-Myers Squibb
- Ashok Dongre
- Discovery Biology, Bristol-Myers Squibb
- Haibo Xue
- The Department of Endocrinology and Metabolism, Binzhou Medical University Hospital
- Stephen D. Miller
- Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
- Youcun Qian
- The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine
- Dolores Hambardzumyan
- Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University
- Tom Hamilton
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- Richard M. Ransohoff
- Biogen Idec
- Xiaoxia Li
- Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation
- DOI
- https://doi.org/10.1038/ncomms15508
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.
