Site-switchable mono-O-allylation of polyols

Hua Tang; Yu-Biao Tian; Hongyan Cui; Ren-Zhe Li; Xia Zhang; Dawen Niu

doi:10.1038/s41467-020-19348-x

Nature Communications (Nov 2020)

Site-switchable mono-O-allylation of polyols

Hua Tang,
Yu-Biao Tian,
Hongyan Cui,
Ren-Zhe Li,
Xia Zhang,
Dawen Niu

Affiliations

Hua Tang: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University
Yu-Biao Tian: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University
Hongyan Cui: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University
Ren-Zhe Li: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University
Xia Zhang: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University
Dawen Niu: Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University

DOI: https://doi.org/10.1038/s41467-020-19348-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

Selective manipulation of one functional group, out of many repeatedly occurring in a substrate, represents a grand challenge in chemistry. Here, the authors report a Pd/Lewis acid cocatalytic system that achieves not only site-selective, but also site-switchable mono-O-allylation of polyols.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal