Nature Communications (Apr 2019)
A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
Abstract
Adventitious oxidation of erythrose-4-phosphate generates 4-phosphoerythronate, which is detoxified by metabolite-proofreading phosphatases in eukaryotes. Here, Sachla & Helmann show that a similar function is carried out in Bacillus subtilis by a checkpoint protein involved in ribosome assembly.