Frontiers in Public Health (Mar 2023)
Wastewater pandemic preparedness: Toward an end-to-end pathogen monitoring program
- Justin R. Clark,
- Justin R. Clark,
- Austen Terwilliger,
- Austen Terwilliger,
- Vasanthi Avadhanula,
- Michael Tisza,
- Michael Tisza,
- Juwan Cormier,
- Juwan Cormier,
- Sara Javornik-Cregeen,
- Sara Javornik-Cregeen,
- Matthew Clayton Ross,
- Matthew Clayton Ross,
- Kristi Louise Hoffman,
- Kristi Louise Hoffman,
- Catherine Troisi,
- Catherine Troisi,
- Blake Hanson,
- Blake Hanson,
- Blake Hanson,
- Joseph Petrosino,
- Joseph Petrosino,
- John Balliew,
- Pedro A. Piedra,
- Pedro A. Piedra,
- Janelle Rios,
- Janelle Rios,
- Jennifer Deegan,
- Jennifer Deegan,
- Cici Bauer,
- Cici Bauer,
- Cici Bauer,
- Fuqing Wu,
- Fuqing Wu,
- Kristina D. Mena,
- Kristina D. Mena,
- Eric Boerwinkle,
- Eric Boerwinkle,
- Eric Boerwinkle,
- Anthony W. Maresso,
- Anthony W. Maresso
Affiliations
- Justin R. Clark
- TAILOR Labs, Baylor College of Medicine, Houston, TX, United States
- Justin R. Clark
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Austen Terwilliger
- TAILOR Labs, Baylor College of Medicine, Houston, TX, United States
- Austen Terwilliger
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Vasanthi Avadhanula
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Michael Tisza
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Michael Tisza
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- Juwan Cormier
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Juwan Cormier
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- Sara Javornik-Cregeen
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Sara Javornik-Cregeen
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- Matthew Clayton Ross
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Matthew Clayton Ross
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- Kristi Louise Hoffman
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Kristi Louise Hoffman
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- Catherine Troisi
- UTHealth Houston School of Public Health, Houston, TX, United States
- Catherine Troisi
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Blake Hanson
- UTHealth Houston School of Public Health, Houston, TX, United States
- Blake Hanson
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Blake Hanson
- Center for Infectious Diseases, Department of Epidemiology, Human Genetics and Environmental Sciences, Houston, TX, United States
- Joseph Petrosino
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Joseph Petrosino
- Alkek Center for Metagenomics and Microbiome Research, CMMR, Baylor College of Medicine, Houston, TX, United States
- John Balliew
- El Paso Water Utility, El Paso, TX, United States
- Pedro A. Piedra
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- Pedro A. Piedra
- Pediatrics Department, Baylor College of Medicine, Houston, TX, United States
- Janelle Rios
- UTHealth Houston School of Public Health, Houston, TX, United States
- Janelle Rios
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Jennifer Deegan
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Jennifer Deegan
- The University of Texas Health Science Center at Houston, Houston, TX, United States
- Cici Bauer
- UTHealth Houston School of Public Health, Houston, TX, United States
- Cici Bauer
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Cici Bauer
- 0Department of Biostatistics and Data Science, UTHealth School of Public Health, Houston, TX, United States
- Fuqing Wu
- UTHealth Houston School of Public Health, Houston, TX, United States
- Fuqing Wu
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Kristina D. Mena
- UTHealth Houston School of Public Health, Houston, TX, United States
- Kristina D. Mena
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Eric Boerwinkle
- UTHealth Houston School of Public Health, Houston, TX, United States
- Eric Boerwinkle
- Texas Epidemic Public Health Institute (TEPHI), UTHealth Houston, Houston, TX, United States
- Eric Boerwinkle
- 1Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, Houston, TX, United States
- Anthony W. Maresso
- TAILOR Labs, Baylor College of Medicine, Houston, TX, United States
- Anthony W. Maresso
- Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States
- DOI
- https://doi.org/10.3389/fpubh.2023.1137881
- Journal volume & issue
-
Vol. 11
Abstract
Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, molecular sciences, temporal-geospatial analytics, epidemiology and medical, and governmental and public health messaging, all of which present their own caveats. Here, we outline a framework for an integrated, state-wide, end-to-end human pathogen monitoring program using wastewater to track viral PPPs.
Keywords
