The Lancet Regional Health. Europe (Nov 2024)
Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohortsResearch in context
- Jesse D. Thacher,
- Nina Roswall,
- Mikael Ögren,
- Andrei Pyko,
- Agneta Åkesson,
- Anna Oudin,
- Annika Rosengren,
- Aslak H. Poulsen,
- Charlotta Eriksson,
- David Segersson,
- Debora Rizzuto,
- Emilie Helte,
- Eva M. Andersson,
- Gunn Marit Aasvang,
- Gunnar Engström,
- Hrafnhildur Gudjonsdottir,
- Jenny Selander,
- Jesper H. Christensen,
- Jørgen Brandt,
- Karin Leander,
- Kim Overvad,
- Kristoffer Mattisson,
- Kristina Eneroth,
- Lara Stucki,
- Lars Barregard,
- Leo Stockfelt,
- Maria Albin,
- Mette K. Simonsen,
- Ole Raaschou-Nielsen,
- Pekka Jousilahti,
- Pekka Tiittanen,
- Petter L.S. Ljungman,
- Steen S. Jensen,
- Susanna Gustafsson,
- Tarja Yli-Tuomi,
- Thomas Cole-Hunter,
- Timo Lanki,
- Youn-Hee Lim,
- Zorana J. Andersen,
- Göran Pershagen,
- Mette Sørensen
Affiliations
- Jesse D. Thacher
- Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark; Corresponding author. Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
- Nina Roswall
- Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark
- Mikael Ögren
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
- Andrei Pyko
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
- Agneta Åkesson
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Anna Oudin
- Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Division of Sustainable Health, Umeå University, Sweden
- Annika Rosengren
- Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
- Aslak H. Poulsen
- Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark
- Charlotta Eriksson
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
- David Segersson
- Swedish Meteorological and Hydrological Institute, Norrköping, Sweden
- Debora Rizzuto
- Aging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Centre, Stockholm, Sweden
- Emilie Helte
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Eva M. Andersson
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
- Gunn Marit Aasvang
- Department of Air Quality and Noise, Norwegian Institute of Public Health, Oslo, Norway
- Gunnar Engström
- Department of Clinical Science, Lund University, Malmö, Sweden
- Hrafnhildur Gudjonsdottir
- Centre for Epidemiology and Community Medicine, Stockholm, Sweden; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden
- Jenny Selander
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Jesper H. Christensen
- Department of Environmental Science, Aarhus University, Roskilde, Denmark
- Jørgen Brandt
- Department of Environmental Science, Aarhus University, Roskilde, Denmark
- Karin Leander
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Kim Overvad
- Department of Public Health, Aarhus University, Aarhus, Denmark
- Kristoffer Mattisson
- Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
- Kristina Eneroth
- Environment and Health Administration, Stockholm, Sweden
- Lara Stucki
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Lars Barregard
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
- Leo Stockfelt
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
- Maria Albin
- Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Mette K. Simonsen
- Department of Neurology and Parker Institute, Bispebjerg and Frederiksberg Hospital, Denmark
- Ole Raaschou-Nielsen
- Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark; Department of Public Health, Aarhus University, Aarhus, Denmark
- Pekka Jousilahti
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- Pekka Tiittanen
- Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland
- Petter L.S. Ljungman
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd Hospital, Stockholm, Sweden
- Steen S. Jensen
- Department of Public Health, Aarhus University, Aarhus, Denmark
- Susanna Gustafsson
- Environmental Department of the City of Malmö, Malmö, Sweden
- Tarja Yli-Tuomi
- Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland
- Thomas Cole-Hunter
- Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Timo Lanki
- Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland; School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland
- Youn-Hee Lim
- Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Zorana J. Andersen
- Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- Göran Pershagen
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- Mette Sørensen
- Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark; Department of Natural Science and Environment, Roskilde University, Denmark
- Journal volume & issue
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Vol. 46
p. 101091
Abstract
Summary: Background: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort. Methods: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution. Findings: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00–1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01–1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1–50 and > 50 dB were associated with HRs of 1.04 (0.93–1.16) and 1.12 (0.98–1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02–1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined. Interpretation: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF. Funding: NordForsk.
