mBio (Jun 2021)
The Membrane Composition Defines the Spatial Organization and Function of a Major Acinetobacter baumannii Drug Efflux System
- Maoge Zang,
- Hugo MacDermott-Opeskin,
- Felise G. Adams,
- Varsha Naidu,
- Jack K. Waters,
- Ashley B. Carey,
- Alex Ashenden,
- Kimberley T. McLean,
- Erin B. Brazel,
- Jhih-Hang Jiang,
- Alessandra Panizza,
- Claudia Trappetti,
- James C. Paton,
- Anton Y. Peleg,
- Ingo Köper,
- Ian T. Paulsen,
- Karl A. Hassan,
- Megan L. O’Mara,
- Bart A. Eijkelkamp
Affiliations
- Maoge Zang
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Hugo MacDermott-Opeskin
- Research School of Chemistry, College of Science, The Australian National University, Canberra, Australian Capital Territory, Australia
- Felise G. Adams
- ORCiD
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Varsha Naidu
- Department of Molecular Sciences, Macquarie University, Sydney, New South Wales, Australia
- Jack K. Waters
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Ashley B. Carey
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Alex Ashenden
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Kimberley T. McLean
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia
- Erin B. Brazel
- ORCiD
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia
- Jhih-Hang Jiang
- ORCiD
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia
- Alessandra Panizza
- Research School of Chemistry, College of Science, The Australian National University, Canberra, Australian Capital Territory, Australia
- Claudia Trappetti
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia
- James C. Paton
- ORCiD
- Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia
- Anton Y. Peleg
- Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia
- Ingo Köper
- ORCiD
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- Ian T. Paulsen
- ORCiD
- Department of Molecular Sciences, Macquarie University, Sydney, New South Wales, Australia
- Karl A. Hassan
- School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
- Megan L. O’Mara
- Research School of Chemistry, College of Science, The Australian National University, Canberra, Australian Capital Territory, Australia
- Bart A. Eijkelkamp
- ORCiD
- Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia
- DOI
- https://doi.org/10.1128/mBio.01070-21
- Journal volume & issue
-
Vol. 12,
no. 3
Abstract
Antimicrobial resistance is an emerging global health crisis. Consequently, we have a critical need to prolong our current arsenal of antibiotics, in addition to the development of novel treatment options.
