Nature Communications (Mar 2016)
The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration
- Georg Gdynia,
- Sven W. Sauer,
- Jürgen Kopitz,
- Dominik Fuchs,
- Katarina Duglova,
- Thorsten Ruppert,
- Matthias Miller,
- Jens Pahl,
- Adelheid Cerwenka,
- Markus Enders,
- Heimo Mairbäurl,
- Marcin M. Kamiński,
- Roland Penzel,
- Christine Zhang,
- Jonathan C. Fuller,
- Rebecca C. Wade,
- Axel Benner,
- Jenny Chang-Claude,
- Hermann Brenner,
- Michael Hoffmeister,
- Hanswalter Zentgraf,
- Peter Schirmacher,
- Wilfried Roth
Affiliations
- Georg Gdynia
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Sven W. Sauer
- Division of Inborn Metabolic Diseases, Department of General Pediatrics, University Children’s Hospital
- Jürgen Kopitz
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Dominik Fuchs
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Katarina Duglova
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Thorsten Ruppert
- Division of Inborn Metabolic Diseases, Department of General Pediatrics, University Children’s Hospital
- Matthias Miller
- German Cancer Research Center, Boveri Junior Research Group Innate Immunity
- Jens Pahl
- German Cancer Research Center, Boveri Junior Research Group Innate Immunity
- Adelheid Cerwenka
- German Cancer Research Center, Boveri Junior Research Group Innate Immunity
- Markus Enders
- Institute of Inorganic Chemistry, Research Group Enders, University of Heidelberg
- Heimo Mairbäurl
- Department of Sports Medicine, Medical Clinic VII, University of Heidelberg, and Translational Lung Research Center (TLRC), member of the German Center for Lung Research (DZL)
- Marcin M. Kamiński
- Division of Immunogenetics, German Cancer Research Center, Tumour Immunology Program
- Roland Penzel
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Christine Zhang
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Jonathan C. Fuller
- Department of Molecular and Cellular Modeling (MCM), Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS)
- Rebecca C. Wade
- Department of Molecular and Cellular Modeling (MCM), Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies (HITS)
- Axel Benner
- Division of Biostatistics, German Cancer Research Center
- Jenny Chang-Claude
- Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Michael Hoffmeister
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Hanswalter Zentgraf
- Division of Monoclonal Antibodies, German Cancer Research Center
- Peter Schirmacher
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- Wilfried Roth
- Department of Surgical Pathology, Institute of Pathology, University of Heidelberg
- DOI
- https://doi.org/10.1038/ncomms10764
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.
