Clinical and Experimental Gastroenterology (Dec 2023)
Personalized Treatment for Crohn’s Disease: Current Approaches and Future Directions
Abstract
Joseph William Clinton, Raymond Keith Cross Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, USACorrespondence: Joseph William Clinton, Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA, Tel +1 703 955 2907, Fax +1 410 328 8318, Email [email protected]: Crohn’s disease is a complex, relapsing and remitting inflammatory disorder of the gastrointestinal tract with a variable disease course. While the treatment options for Crohn’s disease have dramatically increased over the past two decades, predicting individual patient response to treatment remains a challenge. As a result, patients often cycle through multiple different therapies before finding an effective treatment which can lead to disease complications, increased costs, and decreased quality of life. Recently, there has been increased emphasis on personalized medicine in Crohn’s disease to identify individual patients who require early advanced therapy to prevent complications of their disease. In this review, we summarize our current approach to management of Crohn’s disease by identifying risk factors for severe or disabling disease and tailoring individual treatments to patient-specific goals. Lastly, we outline our knowledge gaps in implementing personalized Crohn’s disease treatment and describe the future directions in precision medicine.Keywords: inflammatory bowel disease, precision medicine, personalized medicine, biomarkers, biologic therapy, patient stratification
