Frontiers in Behavioral Neuroscience (Mar 2019)
From Allostatic Load to Allostatic State—An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?
- Enrico Ullmann,
- Enrico Ullmann,
- Enrico Ullmann,
- Seth W. Perry,
- Julio Licinio,
- Ma-Li Wong,
- Eliyahu Dremencov,
- Eliyahu Dremencov,
- Eliyahu Dremencov,
- Evgenii L. Zavjalov,
- Oleg B. Shevelev,
- Nikita V. Khotskin,
- Galina V. Koncevaya,
- Anna S. Khotshkina,
- Mikhail P. Moshkin,
- Maxim S. Lapshin,
- Maria V. Komelkova,
- Inna V. Feklicheva,
- Olga B. Tseilikman,
- Olga P. Cherkasova,
- Kamaldeep S. Bhui,
- Edgar Jones,
- Clemens Kirschbaum,
- Stefan R. Bornstein,
- Stefan R. Bornstein,
- Vadim Tseilikman
Affiliations
- Enrico Ullmann
- Department of Medicine, Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
- Enrico Ullmann
- Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Leipzig, Germany
- Enrico Ullmann
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Seth W. Perry
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States
- Julio Licinio
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States
- Ma-Li Wong
- College of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States
- Eliyahu Dremencov
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Eliyahu Dremencov
- Institute of Molecular Physiology and Genetics, Centre for Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia
- Eliyahu Dremencov
- Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
- Evgenii L. Zavjalov
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Oleg B. Shevelev
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Nikita V. Khotskin
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Galina V. Koncevaya
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Anna S. Khotshkina
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Mikhail P. Moshkin
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia
- Maxim S. Lapshin
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Maria V. Komelkova
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Inna V. Feklicheva
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Olga B. Tseilikman
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- Olga P. Cherkasova
- Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia
- Kamaldeep S. Bhui
- Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom
- Edgar Jones
- 0Institute of Psychiatry Psychology & Neuroscience, King's College London, London, United Kingdom
- Clemens Kirschbaum
- 1Department of Psychology, Biopsychology, Technical University of Dresden, Dresden, Germany
- Stefan R. Bornstein
- Department of Medicine, Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
- Stefan R. Bornstein
- 2Faculty of Life Sciences & Medicine, Endocrinology and Diabetes, Kings College London, London, United Kingdom
- Vadim Tseilikman
- School of Medical Biology, South Ural State University, Chelyabinsk, Russia
- DOI
- https://doi.org/10.3389/fnbeh.2019.00047
- Journal volume & issue
-
Vol. 13
Abstract
The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.
Keywords
