Weurotoxicologic profile of new adenine substances with antiviral activity

Abstract

The aim of the research is to study pharmacological properties and to determine safety effect diapason, toxico-logical properties of new adenine substances 9-[2-(4-isopropylphenopxy) aethyl] adenine under laboratory code VMA-99-82 which obtains antiviral activity in vitro. the results of the research of neurotoxicologic profile of combination of VMA-99-82 are presented in the work using technique of multistage testing according to «S.lrvin». while performing the research it has been established that safety level of substance VMA-99-82 refers to the class of low toxic combination. the diapason of doses (from 18,7 to 300 mg/kg) of substance evident therapeutic effect has been determined. Side-effects are not expressed significantly. therapeutic effect of the combination VMA-99-82 has behavioral reactions. thus the given substance must be further studied for psychotropic effect and its mechanism action

Keywords

• adenine derivatives
• toxicolologic profile
• «S.irvin» test