Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang; Xiang Hu; Mingyan Huang; Juan Liu; Yan Gu; Lijia Ma; Qi Zhou; Xuetao Cao

doi:10.1038/s41467-019-09903-6

Nature Communications (Apr 2019)

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang,
Xiang Hu,
Mingyan Huang,
Juan Liu,
Yan Gu,
Lijia Ma,
Qi Zhou,
Xuetao Cao

Affiliations

Huamin Wang: Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Xiang Hu: Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
Mingyan Huang: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Juan Liu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Yan Gu: National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
Lijia Ma: Westlake Institute for Advanced Study
Qi Zhou: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Xuetao Cao: Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences

DOI: https://doi.org/10.1038/s41467-019-09903-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal