Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants

Abstract

Highlights Whether the incidence and timing of dementia is affected by an interaction of sex with cardiovascular diseases (CVD) events is unclear. We evaluated the sex-specific difference in dementia risk associated with CVDs, including its unique interaction with social, behavioral, genetic, and medical factors. Women with coronary heart disease and heart failure were 1.6 and 1.3 times more likely to develop Alzheimer’s disease than men with the same condition. Men with heart failure had 1.4 times higher risk of having vascular dementia than women. Socioeconomic, lifestyle, genetic, and medical factors moderated the sex-specific association between CVD and dementia.

Keywords

• Sex difference
• Coronary heart diseases
• Stroke
• Heart failure
• Alzheimer’s disease
• Vascular dementia