Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin

Abstract

Yukun Chen,1 Zhenzhi Wang,2 Xiaofan Wang,3 Mingliang Su,1 Fan Xu,1 Lian Yang,1 Lijun Jia,1 Zhanxia Zhang1 1Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China; 2Shaanxi University of Chinese Medicine, Xianyang, 712046, People’s Republic of China; 3Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People’s Republic of ChinaCorrespondence: Lijun Jia; Zhanxia Zhang, Email [email protected]; [email protected]: 10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.Keywords: 10-hydroxycamptothecin, antitumor, nanomedicine, nano-drug delivery systems

Keywords

• 10-hydroxycamptothecin
• antitumor
• nanomedicine
• nano-drug delivery systems