Bispecific antibodies for viral immunotherapy

Abstract

Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies. While the bispecific antibody approach has been applied widely to targets for indications such as cancer and inflammation, the development of such agents for viral immunotherapy is only now emerging. Here, we review recent advances in the development of bispecific antibodies for viral immunotherapy, highlighting promising in vitro and in vivo results.

Keywords

• antibody engineering
• antibody therapeutics
• antiviral
• bifunctional antibodies
• bispecific antibodies
• immunotherapy
• passive immunization
• virology