Nature Communications (Oct 2020)
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations
- Samuel W. Brady,
- Yanling Liu,
- Xiaotu Ma,
- Alexander M. Gout,
- Kohei Hagiwara,
- Xin Zhou,
- Jian Wang,
- Michael Macias,
- Xiaolong Chen,
- John Easton,
- Heather L. Mulder,
- Michael Rusch,
- Lu Wang,
- Joy Nakitandwe,
- Shaohua Lei,
- Eric M. Davis,
- Arlene Naranjo,
- Cheng Cheng,
- John M. Maris,
- James R. Downing,
- Nai-Kong V. Cheung,
- Michael D. Hogarty,
- Michael A. Dyer,
- Jinghui Zhang
Affiliations
- Samuel W. Brady
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Yanling Liu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xiaotu Ma
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Alexander M. Gout
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Kohei Hagiwara
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xin Zhou
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jian Wang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Michael Macias
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xiaolong Chen
- Department of Computational Biology, St. Jude Children’s Research Hospital
- John Easton
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Heather L. Mulder
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Michael Rusch
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Lu Wang
- Department of Pathology, St. Jude Children’s Research Hospital
- Joy Nakitandwe
- Department of Pathology, St. Jude Children’s Research Hospital
- Shaohua Lei
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Eric M. Davis
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Arlene Naranjo
- Department of Biostatistics, University of Florida, Children’s Oncology Group Statistics & Data Center
- Cheng Cheng
- Department of Biostatistics, St. Jude Children’s Research Hospital
- John M. Maris
- Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania
- James R. Downing
- Department of Pathology, St. Jude Children’s Research Hospital
- Nai-Kong V. Cheung
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Michael D. Hogarty
- Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania
- Michael A. Dyer
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-020-18987-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Genomic analysis of neuroblastoma has revealed important disease etiology. In this study, the authors assembled whole genome, exome and transcriptome data from over 700 neuroblastomas and identified molecular signatures correlated with age, and rare, potentially targetable variants overlooked in smaller cohorts.
