Communications Biology (Dec 2020)

In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction

  • Jingyao Wu,
  • Leila J. Mady,
  • Abhijit Roy,
  • Ali Mübin Aral,
  • Boeun Lee,
  • Feng Zheng,
  • Toma Catalin,
  • Youngjae Chun,
  • William R. Wagner,
  • Ke Yang,
  • Humberto E. Trejo Bittar,
  • David Chi,
  • Prashant N. Kumta

DOI
https://doi.org/10.1038/s42003-020-01400-7
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 11

Abstract

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Wu et al. demonstrate utility of a novel, ultrahigh ductility Mg alloy-based biodegradable stent in vitro and in vivo for use in congenital disorders like pediatric laryngotracheal stenosis. Tested in both bioreactor system and rabbit airway model, these stents display higher corrosion resistance and better in vivo degradation without affecting growth of rabbit airway.