Nature Communications (2021-02-01)

Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

  • Benjamin A. H. Jensen,
  • Jacob B. Holm,
  • Ida S. Larsen,
  • Nicole von Burg,
  • Stefanie Derer,
  • Si B. Sonne,
  • Simone I. Pærregaard,
  • Mads V. Damgaard,
  • Stine A. Indrelid,
  • Aymeric Rivollier,
  • Anne-Laure Agrinier,
  • Karolina Sulek,
  • Yke J. Arnoldussen,
  • Even Fjære,
  • André Marette,
  • Inga L. Angell,
  • Knut Rudi,
  • Jonas T. Treebak,
  • Lise Madsen,
  • Caroline Piercey Åkesson,
  • William Agace,
  • Christian Sina,
  • Charlotte R. Kleiveland,
  • Karsten Kristiansen,
  • Tor E. Lea

DOI
https://doi.org/10.1038/s41467-021-21408-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in a dietary control murine model.