Nature Communications (Feb 2021)
Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
- Benjamin A. H. Jensen,
- Jacob B. Holm,
- Ida S. Larsen,
- Nicole von Burg,
- Stefanie Derer,
- Si B. Sonne,
- Simone I. Pærregaard,
- Mads V. Damgaard,
- Stine A. Indrelid,
- Aymeric Rivollier,
- Anne-Laure Agrinier,
- Karolina Sulek,
- Yke J. Arnoldussen,
- Even Fjære,
- André Marette,
- Inga L. Angell,
- Knut Rudi,
- Jonas T. Treebak,
- Lise Madsen,
- Caroline Piercey Åkesson,
- William Agace,
- Christian Sina,
- Charlotte R. Kleiveland,
- Karsten Kristiansen,
- Tor E. Lea
Affiliations
- Benjamin A. H. Jensen
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Jacob B. Holm
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Ida S. Larsen
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Nicole von Burg
- Mucosal Immunology, Department of Health Technology, Technical University of Denmark
- Stefanie Derer
- Institute of Nutritional Medicine, University Hospital Schleswig-Holstein
- Si B. Sonne
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Simone I. Pærregaard
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Mads V. Damgaard
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Stine A. Indrelid
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- Aymeric Rivollier
- Mucosal Immunology, Department of Health Technology, Technical University of Denmark
- Anne-Laure Agrinier
- Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University
- Karolina Sulek
- Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Metabolism and Environmental Influences, Faculty of Health and Medical Sciences, University of Copenhagen
- Yke J. Arnoldussen
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- Even Fjære
- Institute of Marine Research
- André Marette
- Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University
- Inga L. Angell
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- Knut Rudi
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- Jonas T. Treebak
- Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Metabolism and Environmental Influences, Faculty of Health and Medical Sciences, University of Copenhagen
- Lise Madsen
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Caroline Piercey Åkesson
- Department of Anatomy and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences
- William Agace
- Mucosal Immunology, Department of Health Technology, Technical University of Denmark
- Christian Sina
- Institute of Nutritional Medicine, University Hospital Schleswig-Holstein
- Charlotte R. Kleiveland
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- Karsten Kristiansen
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen
- Tor E. Lea
- Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences
- DOI
- https://doi.org/10.1038/s41467-021-21408-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in a dietary control murine model.
