Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

Yin-Feng Kang; Cong Sun; Jing Sun; Chu Xie; Zhen Zhuang; Hui-Qin Xu; Zheng Liu; Yi-Hao Liu; Sui Peng; Run-Yu Yuan; Jin-Cun Zhao; Mu-Sheng Zeng

doi:10.1038/s41467-022-30222-w

Nature Communications (May 2022)

Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

Yin-Feng Kang,
Cong Sun,
Jing Sun,
Chu Xie,
Zhen Zhuang,
Hui-Qin Xu,
Zheng Liu,
Yi-Hao Liu,
Sui Peng,
Run-Yu Yuan,
Jin-Cun Zhao,
Mu-Sheng Zeng

Affiliations

Yin-Feng Kang: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Cong Sun: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Jing Sun: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University
Chu Xie: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
Zhen Zhuang: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University
Hui-Qin Xu: Cryo-electron Microscopy Center, Southern University of Science and Technology
Zheng Liu: Cryo-electron Microscopy Center, Southern University of Science and Technology
Yi-Hao Liu: Institute of Precision Medicine, Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University
Sui Peng: Institute of Precision Medicine, Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University
Run-Yu Yuan: Guangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention
Jin-Cun Zhao: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University
Mu-Sheng Zeng: State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Experimental Research, Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-022-30222-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

Emerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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