Nature Communications (May 2022)

Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

  • Yin-Feng Kang,
  • Cong Sun,
  • Jing Sun,
  • Chu Xie,
  • Zhen Zhuang,
  • Hui-Qin Xu,
  • Zheng Liu,
  • Yi-Hao Liu,
  • Sui Peng,
  • Run-Yu Yuan,
  • Jin-Cun Zhao,
  • Mu-Sheng Zeng

DOI
https://doi.org/10.1038/s41467-022-30222-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Emerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mice.