Immune cell infiltration pattern in non-small cell lung cancer PDX models is a model immanent feature and correlates with a distinct molecular and phenotypic make-up

• Simone Gaedicke,
• Gabriele Niedermann,
• Anne Grote,
• Friedrich Feuerhake,
• Eva Oswald,
• Kanstantsin Lashuk,
• Daniel Bug,
• Nassim Bouteldja,
• Dorothee Lenhard,
• Anne Löhr,
• Anke Behnke,
• Volker Knauff,
• Anna Edinger,
• Kerstin Klingner,
• Dorit Merhof,
• Julia Schueler

Affiliations

Simone Gaedicke

Aff1 grid.5963.9Department of Radiation OncologyMedical Center, Faculty of Medicine, University of Freiburg Freiburg Germany

Gabriele Niedermann

Aff1 grid.5963.9Department of Radiation OncologyMedical Center, Faculty of Medicine, University of Freiburg Freiburg Germany

Anne Grote

1Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Friedrich Feuerhake

Institute of Pathology, Medical School Hannover, Hannover, Germany

Eva Oswald

2Charles River Research Services Germany, Freiburg, Germany

Kanstantsin Lashuk

2Charles River Research Services Germany, Freiburg, Germany

Daniel Bug

Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany

Nassim Bouteldja

Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany

Dorothee Lenhard

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Anne Löhr

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Anke Behnke

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Volker Knauff

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Anna Edinger

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Kerstin Klingner

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany

Dorit Merhof

Institute of Imaging and Computer Vision, RWTH Aachen University, Aachen, Germany

Julia Schueler

Charles River Discovery Research Services Gemany GmbH, Charles River Laboratories Inc, Freiburg, Germany