Nature Communications (Apr 2017)
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
- Jun Fang,
- Jinping Jia,
- Matthew Makowski,
- Mai Xu,
- Zhaoming Wang,
- Tongwu Zhang,
- Jason W. Hoskins,
- Jiyeon Choi,
- Younghun Han,
- Mingfeng Zhang,
- Janelle Thomas,
- Michael Kovacs,
- Irene Collins,
- Marta Dzyadyk,
- Abbey Thompson,
- Maura O'Neill,
- Sudipto Das,
- Qi Lan,
- Roelof Koster,
- PanScan Consortium,
- TRICL Consortium,
- GenoMEL Consortium,
- Rachael S. Stolzenberg-Solomon,
- Peter Kraft,
- Brian M. Wolpin,
- Pascal W. T. C. Jansen,
- Sara Olson,
- Katherine A. McGlynn,
- Peter A. Kanetsky,
- Nilanjan Chatterjee,
- Jennifer H. Barrett,
- Alison M. Dunning,
- John C. Taylor,
- Julia A. Newton-Bishop,
- D. Timothy Bishop,
- Thorkell Andresson,
- Gloria M. Petersen,
- Christopher I. Amos,
- Mark M. Iles,
- Katherine L. Nathanson,
- Maria Teresa Landi,
- Michiel Vermeulen,
- Kevin M. Brown,
- Laufey T. Amundadottir
Affiliations
- Jun Fang
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Jinping Jia
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Matthew Makowski
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Mai Xu
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Zhaoming Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Tongwu Zhang
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Jason W. Hoskins
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Jiyeon Choi
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Younghun Han
- Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College
- Mingfeng Zhang
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Janelle Thomas
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Michael Kovacs
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Irene Collins
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Marta Dzyadyk
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Abbey Thompson
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Maura O'Neill
- Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
- Sudipto Das
- Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
- Qi Lan
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Roelof Koster
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- PanScan Consortium
- TRICL Consortium
- GenoMEL Consortium
- Rachael S. Stolzenberg-Solomon
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Peter Kraft
- Department of Epidemiology, Harvard School of Public Health
- Brian M. Wolpin
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Pascal W. T. C. Jansen
- Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University
- Sara Olson
- Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center
- Katherine A. McGlynn
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Peter A. Kanetsky
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
- Nilanjan Chatterjee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jennifer H. Barrett
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Alison M. Dunning
- Department of Oncology, University of Cambridge
- John C. Taylor
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Julia A. Newton-Bishop
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- D. Timothy Bishop
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Thorkell Andresson
- Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
- Gloria M. Petersen
- Department of Health Sciences Research, Mayo Clinic
- Christopher I. Amos
- Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College
- Mark M. Iles
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Katherine L. Nathanson
- Department of Medicine and Abramson Cancer Center, Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Michiel Vermeulen
- Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University
- Kevin M. Brown
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- Laufey T. Amundadottir
- Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms15034
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.
