Frontiers in Cell and Developmental Biology (Dec 2021)
mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
- Qinqin Peng,
- Qinqin Peng,
- Qinqin Peng,
- Qinqin Peng,
- Ke Sha,
- Ke Sha,
- Ke Sha,
- Ke Sha,
- Yingzi Liu,
- Yingzi Liu,
- Yingzi Liu,
- Yingzi Liu,
- Mengting Chen,
- Mengting Chen,
- Mengting Chen,
- Mengting Chen,
- San Xu,
- San Xu,
- San Xu,
- San Xu,
- Hongfu Xie,
- Hongfu Xie,
- Hongfu Xie,
- Hongfu Xie,
- Zhili Deng,
- Zhili Deng,
- Zhili Deng,
- Zhili Deng,
- Zhili Deng,
- Ji Li,
- Ji Li,
- Ji Li,
- Ji Li,
- Ji Li
Affiliations
- Qinqin Peng
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Qinqin Peng
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Qinqin Peng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Qinqin Peng
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Ke Sha
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Ke Sha
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Ke Sha
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Ke Sha
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Yingzi Liu
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Yingzi Liu
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Yingzi Liu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Yingzi Liu
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Mengting Chen
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Mengting Chen
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Mengting Chen
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Mengting Chen
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- San Xu
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- San Xu
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- San Xu
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- San Xu
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Hongfu Xie
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Hongfu Xie
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Hongfu Xie
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Hongfu Xie
- Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, China
- Zhili Deng
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Zhili Deng
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Zhili Deng
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Zhili Deng
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Zhili Deng
- Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, China
- Ji Li
- Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
- Ji Li
- Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China
- Ji Li
- National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
- Ji Li
- Key Laboratory of Molecular Radiation Oncology of Hunan Province, Changsha, China
- Ji Li
- Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fcell.2021.751785
- Journal volume & issue
-
Vol. 9
Abstract
Although multiple evidences suggest that angiogenesis is associated with the pathophysiology of rosacea, its role is still in debate. Here, we showed that angiogenesis was enhanced in skin lesions of both rosacea patients and LL37-induced rosacea-like mice. Inhibition of angiogenesis alleviated LL37-induced rosacea-like features in mice. Mechanistically, we showed that mTORC1 was activated in the endothelial cells of the lesional skin from rosacea patients and LL37-induced rosacea-like mouse model. Inhibition of mTORC1 decreased angiogenesis and blocked the development of rosacea in mice. On the contrary, hyperactivation of mTORC1 increased angiogenesis and exacerbated rosacea-like phenotypes. Our in vitro results further demonstrated that inhibition of mTORC1 signaling significantly declined LL37-induced tube formation of human endothelial cells. Taken together, our findings revealed that mTORC1-mediated angiogenesis responding to LL37 might be essential for the development of rosacea and targeting angiogenesis might be a novel potential therapy.
Keywords
