Nature Communications (Apr 2021)

Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

  • Bo-Shuai Mu,
  • Xiao-Yuan Cui,
  • Xing-Ping Zeng,
  • Jin-Sheng Yu,
  • Jian Zhou

DOI
https://doi.org/10.1038/s41467-021-22374-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridines from N-Boc aldimines, aldehydes and phosphoranes, using a chiral amine catalyst.