Nature Communications (Apr 2019)
Breast cancer quantitative proteome and proteogenomic landscape
- Henrik J. Johansson,
- Fabio Socciarelli,
- Nathaniel M. Vacanti,
- Mads H. Haugen,
- Yafeng Zhu,
- Ioannis Siavelis,
- Alejandro Fernandez-Woodbridge,
- Miriam R. Aure,
- Bengt Sennblad,
- Mattias Vesterlund,
- Rui M. Branca,
- Lukas M. Orre,
- Mikael Huss,
- Erik Fredlund,
- Elsa Beraki,
- Øystein Garred,
- Jorrit Boekel,
- Torill Sauer,
- Wei Zhao,
- Silje Nord,
- Elen K. Höglander,
- Daniel C. Jans,
- Hjalmar Brismar,
- Tonje H. Haukaas,
- Tone F. Bathen,
- Ellen Schlichting,
- Bjørn Naume,
- Consortia Oslo Breast Cancer Research Consortium (OSBREAC),
- Torben Luders,
- Elin Borgen,
- Vessela N. Kristensen,
- Hege G. Russnes,
- Ole Christian Lingjærde,
- Gordon B. Mills,
- Kristine K. Sahlberg,
- Anne-Lise Børresen-Dale,
- Janne Lehtiö
Affiliations
- Henrik J. Johansson
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Fabio Socciarelli
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Nathaniel M. Vacanti
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Mads H. Haugen
- Department of Tumor Biology and Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Yafeng Zhu
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Ioannis Siavelis
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Alejandro Fernandez-Woodbridge
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Miriam R. Aure
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Bengt Sennblad
- Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University
- Mattias Vesterlund
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Rui M. Branca
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Lukas M. Orre
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Mikael Huss
- Department of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm University
- Erik Fredlund
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Elsa Beraki
- Department of Pathology, Oslo University Hospital
- Øystein Garred
- Department of Pathology, Oslo University Hospital
- Jorrit Boekel
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- Torill Sauer
- Department of Pathology, Akershus University Hospital
- Wei Zhao
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Silje Nord
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Elen K. Höglander
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Daniel C. Jans
- Department of Applied Physics, KTH Royal Institute of Technology
- Hjalmar Brismar
- Department of Applied Physics, KTH Royal Institute of Technology
- Tonje H. Haukaas
- Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology – NTNU
- Tone F. Bathen
- Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology – NTNU
- Ellen Schlichting
- Section for Breast- and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital
- Bjørn Naume
- Institute for Clinical Medicine, University of Oslo
- Consortia Oslo Breast Cancer Research Consortium (OSBREAC)
- Torben Luders
- Institute for Clinical Medicine, University of Oslo
- Elin Borgen
- Department of Pathology, Oslo University Hospital
- Vessela N. Kristensen
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Hege G. Russnes
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Ole Christian Lingjærde
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Gordon B. Mills
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Kristine K. Sahlberg
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Anne-Lise Børresen-Dale
- Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital
- Janne Lehtiö
- Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-09018-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Gene expression profiles can classify breast cancer into five clinically relevant subtypes. Here, the authors perform an in-depth quantitative profiling of the proteome of 45 breast tumors, and show they can recapitulate the transcriptome-based classifications and identify many potentially antigenic tumour-specific peptides.
