Nature Communications (Feb 2019)

Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine

  • Shengqing Zhu,
  • Jian Qin,
  • Fang Wang,
  • Huan Li,
  • Lingling Chu

DOI
https://doi.org/10.1038/s41467-019-08669-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Alkenylpyridines are versatile building blocks for the synthesis of drugs and other complex molecular structures. Here, the authors show a branch-selective pyridylation of alkenes via sulfinate-assisted photoredox catalysis and showcase its utility in an expedient synthesis of Triprolidine.