Endocrine Regulations (Jan 2023)

Correlation between the size of pheochromocytoma and the level of metanephrines

  • Rezkallah Emad,
  • Elsaify Andrew,
  • Hanna Ragai,
  • Elsaify Wael

DOI
https://doi.org/10.2478/enr-2023-0022
Journal volume & issue
Vol. 57, no. 1
pp. 183 – 190

Abstract

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Objective. Pheochromocytomas (PHEO) and paraganglioma (PGLs) are rare neuroendocrine catecholamine-producing tumors that arise from the chromaffin cells of either the adrenal medulla or extra-adrenal paraganglionic tissues. Despite the recent advances in imaging technologies, biochemical evidence of excessive catecholamine production by the tumor is considered the most important test for the diagnosis of these tumors. The aim of the present study is to investigate the role of the catecholamine metabolites (normetanephrine and metanephrine) levels in the diagnosis of PHEO/PGLs and to evaluate if their levels correlate with the size of these tumors.

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