704 The computationally designed human antibody, AU-007, mediates human immune activation by endogenous IL-2, while uniquely breaking the IL-2 auto-inhibitory loop and preventing Treg expansion

• Timothy Wyant,
• James Vasselli,
• Inbar Amit,
• Itay Levin,
• Natali Levitan,
• Reut Barak,
• May Ben-Mayor,
• Olga Bluvshtein,
• Noam Grossman,
• Yehezkel Sasson,
• Guy Nimrod,
• Michael Zehnin,
• Sharon Fischman,
• Marek Štrajbl,
• Liron Danielpur,
• Aron Knickerbocker,
• Yanay Ofran

Affiliations

Timothy Wyant

Aff81 grid.421631.30000000404088900Curis, Inc. Lexington MA USA

James Vasselli

Aff424 grid.421076.60000000404326278MacroGenics, Inc. Rockville MD USA

Inbar Amit

1Biolojic Design, Rehovot, Israel

Itay Levin

1Biolojic Design, Rehovot, Israel

Natali Levitan

1Biolojic Design, Rehovot, Israel

Reut Barak

1Biolojic Design, Rehovot, Israel

May Ben-Mayor

1Biolojic Design, Rehovot, Israel

Olga Bluvshtein

1Biolojic Design, Rehovot, Israel

Noam Grossman

1Biolojic Design, Rehovot, Israel

Yehezkel Sasson

1Biolojic Design, Rehovot, Israel

Guy Nimrod

1Biolojic Design, Rehovot, Israel

Michael Zehnin

1Biolojic Design, Rehovot, Israel

Sharon Fischman

1Biolojic Design, Rehovot, Israel

Marek Štrajbl

1Biolojic Design, Rehovot, Israel

Liron Danielpur

1Biolojic Design, Rehovot, Israel

Aron Knickerbocker

3Aulos Bioscience, LARKSPUR, CA, United States

Yanay Ofran

4Aulos Bioscience & Biolojic Design, Rehovot, Israel