Activity of blood kallikrein-kinin and renin-angiotensin systemsin newborns with hypoxic-ishaemic encephalopathy

Abstract

Oxygen insufficiency in newborns is associated with disturbed vascular tone, which are regulated by kallikrein-kinin (KKS) and renin-angiotensin systems (RAS).Important index of hemodynamic disturbances is the activity of kallikrein, of angiotensin-converting enzyme (ACE) and also inhibitors of proteinases: α1-proteinase inhibitor and α2-macroglobulin. In hypoxic-ischemic encephalopathy of mature newborns and children of the I, II premature degrees , blood KKS activity is increased in comparison with RAS. Decreased activity of α1-proteinase inhibitor is seen in 46% of premature infants of II degree which usually leads to chronic pathologic process. The increased activity of ACE is important for preventing hemodynamic disturbances.

Keywords

• калликреин
• ангиотензинпревращающий фермент
• a1-протеиназный ингибитор
• доношенные и недоношенные новорожденные