Synthesis of new water-soluble ionic liquids and their antibacterial profile against gram-positive and gram-negative bacteria
Ali Niyazi Duman,
Ismail Ozturk,
Ayça Tunçel,
Kasim Ocakoglu,
Suleyman Gokhan Colak,
Mine Hoşgör-Limoncu,
Fatma Yurt
Affiliations
Ali Niyazi Duman
Department of Material Science and Engineering, Ege University, Bornova, Izmir, 35100, Turkey
Ismail Ozturk
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Izmir Katip Celebi University, Cigli, Izmir, 35620, Turkey
Ayça Tunçel
Institute of Nuclear Science, Department of Nuclear Applications, Ege University, Bornova, Izmir, 35100, Turkey
Kasim Ocakoglu
Department of Energy Systems Engineering, Faculty of Technology, Tarsus University, Tarsus, TR-33480, Turkey; Corresponding author.
Suleyman Gokhan Colak
Department of Energy Systems Engineering, Faculty of Technology, Tarsus University, Tarsus, TR-33480, Turkey
Mine Hoşgör-Limoncu
Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ege University, Bornova, Izmir, 35100, Turkey
Fatma Yurt
Department of Material Science and Engineering, Ege University, Bornova, Izmir, 35100, Turkey; Institute of Nuclear Science, Department of Nuclear Applications, Ege University, Bornova, Izmir, 35100, Turkey; Corresponding author.
A series of imidazolium bromide salts (NIM-Br 1a, 1b and 1c) bearing different lengths of alkyl chains were synthesized and theirin vitro antibacterial activities were determined by measuring the minimum inhibitory concentration (MIC) values for Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Enterococcus faecalis. In addition, these imidazolium derivatives were also evaluated against biofilm produced by these bacterial strains. All compounds were found to be effective against Gram-positive and Gram-negative bacteria, and also more effective on the S. aureus biofilm production than the others.
