PLoS Neglected Tropical Diseases (Jan 2016)

Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.

  • Gloria Morizot,
  • Romain Jouffroy,
  • Albert Faye,
  • Paul Chabert,
  • Katia Belhouari,
  • Ruxandra Calin,
  • Caroline Charlier,
  • Patrick Miailhes,
  • Jean-Yves Siriez,
  • Oussama Mouri,
  • Hélène Yera,
  • Jacques Gilquin,
  • Roland Tubiana,
  • Fanny Lanternier,
  • Marie-France Mamzer,
  • Christophe Legendre,
  • Dominique Peyramond,
  • Eric Caumes,
  • Olivier Lortholary,
  • Pierre Buffet

DOI
https://doi.org/10.1371/journal.pntd.0004304
Journal volume & issue
Vol. 10, no. 1
p. e0004304

Abstract

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We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.