Communications Chemistry (Sep 2021)

Direct alkylation of N,N-dialkyl benzamides with methyl sulfides under transition metal-free conditions

  • Can-Can Bao,
  • Hui-Zhen Du,
  • Yan-Long Luo,
  • Bing-Tao Guan

DOI
https://doi.org/10.1038/s42004-021-00575-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 8

Abstract

Read online

Direct conversion of amides to ketones typically requires the use of transition metal catalysts or reactive organometallic reagents. Here the direct alkylation of benzamides with methyl sulfides using LDA as base provides access to thioalkoxyketones.