Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease
Jiahui Si,
Jiachen Li,
Canqing Yu,
Yu Guo,
Zheng Bian,
Iona Millwood,
Ling Yang,
Robin Walters,
Yiping Chen,
Huaidong Du,
Li Yin,
Jianwei Chen,
Junshi Chen,
Zhengming Chen,
Liming Li,
Liming Liang,
Jun Lv
Affiliations
Jiahui Si
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States
Jiachen Li
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China
Canqing Yu
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, China
Yu Guo
Chinese Academy of Medical Sciences, Beijing, China
Zheng Bian
Chinese Academy of Medical Sciences, Beijing, China
Iona Millwood
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Ling Yang
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Robin Walters
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Yiping Chen
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Huaidong Du
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Li Yin
NCDs Prevention and Control Department, Hunan Center for Disease Control & Prevention, Changsha, China
Jianwei Chen
Liuyang Center for Disease Control & Prevention, Liuyang, Hunan, China
Junshi Chen
China National Center for Food Safety Risk Assessment, Beijing, China
Zhengming Chen
Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Liming Li
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, China
Liming Liang
Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, China
Adherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study of 4681 participants nested in the prospective China Kadoorie Biobank, 61 lipidomic markers in baseline plasma were measured by targeted nuclear magnetic resonance spectroscopy. Baseline lifestyles included smoking, alcohol consumption, dietary habit, physical activity, and adiposity levels. Genetic instrument was used to mimic the lipid-lowering effect of statins. We found that 35 lipid metabolites showed statistically significant mediation effects in the pathway from healthy lifestyles to CHD reduction, including very low-density lipoprotein (VLDL) particles and their cholesterol, large-sized high-density lipoprotein (HDL) particle and its cholesterol, and triglyceride in almost all lipoprotein subfractions. The statins genetic score was associated with reduced intermediate- and low-density lipoprotein, but weak or no association with VLDL and HDL. Lifestyle interventions and statins may improve different components of the lipid profile.
