F-actin architecture determines constraints on myosin thick filament motion

Camelia G. Muresan; Zachary Gao Sun; Vikrant Yadav; A. Pasha Tabatabai; Laura Lanier; June Hyung Kim; Taeyoon Kim; Michael P. Murrell

doi:10.1038/s41467-022-34715-6

Nature Communications (Nov 2022)

F-actin architecture determines constraints on myosin thick filament motion

Camelia G. Muresan,
Zachary Gao Sun,
Vikrant Yadav,
A. Pasha Tabatabai,
Laura Lanier,
June Hyung Kim,
Taeyoon Kim,
Michael P. Murrell

Affiliations

Camelia G. Muresan: Department of Biomedical Engineering, Yale University
Zachary Gao Sun: Systems Biology Institute, Yale University
Vikrant Yadav: Department of Biomedical Engineering, Yale University
A. Pasha Tabatabai: Department of Biomedical Engineering, Yale University
Laura Lanier: Department of Biomedical Engineering, Yale University
June Hyung Kim: Weldon School of Biomedical Engineering, Purdue University
Taeyoon Kim: Weldon School of Biomedical Engineering, Purdue University
Michael P. Murrell: Department of Biomedical Engineering, Yale University

DOI: https://doi.org/10.1038/s41467-022-34715-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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While the impact of F-actin architecture on stress transmission is well studied, the role of architecture on stress generation remains unclear. Here authors use in vitro model and show that distinct organizations constrain myosin motion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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