Diagnostics
(Dec 2022)
The Pitfall of Ganglioneuroblastoma-Nodular Diagnosis: Clinical and Imaging Considerations over a Rare Bifocal Sporadic Case
Claudio Montante,
Francesco Fabozzi,
Maria Felicia Villani,
Maria Luisa D’Andrea,
Alessandra Stracuzzi,
Gian Luigi Natali,
Giada Del Baldo,
Francesca Del Bufalo,
Maria Carmen Garganese,
Annalisa Serra,
Paolo Tomà,
Rita Alaggio,
Sabina Vennarini,
Giovanna Stefania Colafati,
Angela Mastronuzzi,
Maria Antonietta De Ioris
Affiliations
Claudio Montante
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Francesco Fabozzi
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Maria Felicia Villani
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Maria Luisa D’Andrea
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Alessandra Stracuzzi
Department of Pathology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Gian Luigi Natali
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Giada Del Baldo
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Francesca Del Bufalo
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Maria Carmen Garganese
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Annalisa Serra
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Paolo Tomà
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Rita Alaggio
Department of Pathology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Sabina Vennarini
Pediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy
Giovanna Stefania Colafati
Department of Imaging, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Angela Mastronuzzi
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
Maria Antonietta De Ioris
Department of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
DOI
https://doi.org/10.3390/diagnostics12123221
Journal volume & issue
Vol. 12,
no. 12
Abstract
Read online
Neuroblastic tumors (NTs) represent the most common extracranial neoplasm occurring in childhood. Although ganglioneuroblastoma intermixed (GNBI) and ganglioneuroma (GN) are classified as very low-risk tumors, neuroblastoma (NB) and ganglioneuroblastoma-nodular (GNBN) may represent a serious risk to survival. Unfortunately, areas of GNBI and GNBN can coexist in the same mass, leading to incorrect risk staging when only biopsy is performed. Herein, we describe a case of multifocal NT (thoracic and abdominal localization) occurring in a 4-year-old male. Different histological subtypes, namely GNBI and GNBN, were revealed in the two lesions. We focus on the difficulties of proper diagnosis and risk stratification, underlining the usefulness of several diagnostic tools for appropriate management and therapeutic choices.
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