Recovery Period for Attaining Baseline Haematological Prameters after Plateletpheresis Donation- A Cohort Study

Abstract

Introduction: Plateletpheresis provides the advantage of collecting a large volume of platelets, equivalent to a platelet count of 20-40 x 109 in a single unit. The risk of postdonation anaemia is reduced as the red cells are re-infused into the donor. Plateletpheresis affects the donors, haematological parameters and their period for reaching the baseline is important. Aim: To analyse the recovery of haematological parameters to baseline among apheresis platelet donors. Materials and Methods: A cohort study was conducted at the Department of Pathology, Pramukh Swami Medical College from April 2020 to September 2021. The study included 40 plateletpheresis procedures, which were performed according to manufacturer’s manual and standard operating procedure. The donor’s samples were assessed on immediate postdonation, on second, seventh, and fourteenth postdonation day. The age, weight, height of patient, Haemoglobin (Hb) concentration, Total Leucocyte Count (TLC), and platelet were also noted. Paired t-test was applied for the comparison of pre and post plateletpheresis values of haematological parameters. The p-value <0.05 was considered statistically significant. Data analysis was done with the help of Statistical Package for Social Sciences (SPSS) Version 15. Results: Post plateletpheresis the platelet count reached the baseline on the fourteenth day whereas, the total White Blood Cells (WBC) count and Hb reached the baseline on the seventh day. The donors who were preobese were maximum in number and the duration of procedure was comparatively lower in them. Conclusion: The platelet count reached the baseline by the fourteenth day while the other haematological parameters reached the baseline by the seventh day. Therefore, a minimum interval of seven days would suffice to ensure the baseline return of the haematological parameters in the best interest of the donor’s health.

Keywords

• haematocrit
• platelet count
• platelet distribution width
• platelet large cell ratio