Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies

GUO Qing; RAO Qiu; ZHOU Zhiyi

doi:10.3971/j.issn.1000-8578.2019.18.1871

Zhongliu Fangzhi Yanjiu (Jul 2019)

Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies

GUO Qing,
RAO Qiu,
ZHOU Zhiyi

Affiliations

GUO Qing: Department of Pathology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China
RAO Qiu: Department of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, China
ZHOU Zhiyi: Department of Pathology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

DOI: https://doi.org/10.3971/j.issn.1000-8578.2019.18.1871
Journal volume & issue: Vol. 46, no. 7
pp. 644 – 649

Abstract

Read online

The SWI/SNF complex is an important multi-subunit protein complex that regulates gene expression in eukaryotic cells. It is widely involved in various biological processes such as signal transduction, cell cycle and cell differentiation. SWI/SNF complex subunit mutations occur in more than 20% of malignant tumors. This article reviews the role and characteristics of this complex and its subunits in malignant tumors, and explores the potential clinical application of SWI/SNF complexes in tumor therapy.

Published in Zhongliu Fangzhi Yanjiu

ISSN: 1000-8578 (Print)
Publisher: Magazine House of Cancer Research on Prevention and Treatment
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.zlfzyj.com

About the journal

Abstract

Keywords