A Social Stimulation Paradigm to Ameliorate Memory Deficit in Alzheimer's Disease
Qiaoyun Ren,
Susu Wang,
Wei Xie,
An Liu
Affiliations
Qiaoyun Ren
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, Nanjing, ChinaInstitute for Brain and Intelligence, Southeast University, Nanjing, China
Susu Wang
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, Nanjing, ChinaInstitute for Brain and Intelligence, Southeast University, Nanjing, China
Wei Xie
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, Nanjing, ChinaInstitute for Brain and Intelligence, Southeast University, Nanjing, China
An Liu
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, Nanjing, ChinaInstitute for Brain and Intelligence, Southeast University, Nanjing, China, Shenzhen Research Institute, Southeast University, Shenzhen, China
Alzheimer's disease (AD) poses a global health threat, progressively robbing patients of their memory and cognitive abilities. While it is recognized that meaningful social contact can alleviate the symptoms of dementia in AD patients, the precise mechanisms by which social stimulation mitigates AD symptoms remain poorly understood. We found that social interaction with novel mice, also known as novel social, simulated meaningful socializing. Therefore, we developed the multiple novel social (MNS) stimulation paradigm to train AD model mice and found that MNS effectively alleviated cognitive deficits in AD mice. This discovery not only opens up a new avenue for investigating the relationship between social stimulation and Alzheimer's disease but also lays the groundwork for delving into the underlying mechanisms, thereby providing crucial theoretical support for developing novel strategies to treat Alzheimer's disease.
