POLYMORPHISM OF PREDISPOSITION GENES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ARTERIAL HYPERTENSION IN GERIATRIC PATIENTS

Abstract

Aim. To assess the associations between predisposition genes (TGF-p1, HHIP, IL6R, SOD3, and CHRNA3), in relation to peripheral vascular structure and function, endothelial dysfunction, and cytokine status, in geriatric patients with chronic obstructive pulmonary disease (COPD) and arterial hypertension (AH). Material and methods. In total, 154 geriatric patients with either isolated AH or the combination of AH and COPD underwent clinical, functional, laboratory, ultrasound, and cytogenetic examination.Results. The key associations between predisposition genes, in relation to peripheral vascular structure and function, endothelial dysfunction, and cytokine status, were identified in geriatric patients with COPD and AH who received short- or long-acting inhaled M-cholinolytics and steroids combined with perindopril monotherapy (10 mg/day; Prestarium, Servier Laboratories, France).Conclusion. The combination of COPD and AH was characterised by significantly different distribution of genotypes and alleles (TGFB1 gene rs1804470 allele and HHIP gene rs1828591 allele), in relation to geriatric age. Patients with the COPD and AH combination had more severe endothelial dysfunction, cytokine activation, and disturbed structure and function of peripheral vessels (distal-proximal type). There were significant differences in peripheral vascular remodelling parameters among elderly vs. very elderly patients with COPD and AH.

Keywords

• mononucleotide genetic polymorphism
• geriatric age
• arterial hypertension
• chronic obstructive pulmonary disease
• vascular remodelling
• endothelial dysfunction