Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Abstract

AbstractAim: Analysis of the data of children following stem cell transplantation.Materials and Methods: A total of 44 children who received stem cell transplant between February 2009 and May 2011 were evaluated retrospectively. Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were female. The initial diagnosis of the patients with decreasing order of frequency was as follows: thalassemia major (n=15), acute leukemia (n=9), Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9). Disease-free survival in two years was observed in 27 (61.3%) of patients. Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The mortality was transplant-related in two cases, whereas it was due to progression of the underlying disease in 7 (15.9%) patients. Conclusion: As the stem cell transplantation has become widespread in Türkiye recently, its data are valuable. We found high incidence of mucositis and infection due to myeloablative regimens. The limitation of our study is the small number of patients included. Though, results obtained here are similar to those of national and international studies.

Keywords

• hematopoietic stem cell transplantation
• prognosis
• transplant-related mortality