Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

Gajanan D. Katkar; Ibrahim M. Sayed; Mahitha Shree Anandachar; Vanessa Castillo; Eleadah Vidales; Daniel Toobian; Fatima Usmani; Joseph R. Sawires; Geoffray Leriche; Jerry Yang; William J. Sandborn; Soumita Das; Debashis Sahoo; Pradipta Ghosh

doi:10.1038/s42003-022-03168-4

Communications Biology (Mar 2022)

Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease

Gajanan D. Katkar,
Ibrahim M. Sayed,
Mahitha Shree Anandachar,
Vanessa Castillo,
Eleadah Vidales,
Daniel Toobian,
Fatima Usmani,
Joseph R. Sawires,
Geoffray Leriche,
Jerry Yang,
William J. Sandborn,
Soumita Das,
Debashis Sahoo,
Pradipta Ghosh

Affiliations

Gajanan D. Katkar: Department of Cellular and Molecular Medicine, University of California San Diego
Ibrahim M. Sayed: Department of Pathology, University of California San Diego
Mahitha Shree Anandachar: Department of Pathology, University of California San Diego
Vanessa Castillo: Department of Cellular and Molecular Medicine, University of California San Diego
Eleadah Vidales: Department of Cellular and Molecular Medicine, University of California San Diego
Daniel Toobian: Department of Cellular and Molecular Medicine, University of California San Diego
Fatima Usmani: Department of Pathology, University of California San Diego
Joseph R. Sawires: Department of Chemistry and Biochemistry, University of California San Diego
Geoffray Leriche: Department of Chemistry and Biochemistry, University of California San Diego
Jerry Yang: Department of Chemistry and Biochemistry, University of California San Diego
William J. Sandborn: Department of Medicine, University of California San Diego
Soumita Das: Department of Pathology, University of California San Diego
Debashis Sahoo: Department of Computer Science and Engineering, Jacob’s School of Engineering, University of California San Diego
Pradipta Ghosh: Department of Cellular and Molecular Medicine, University of California San Diego

DOI: https://doi.org/10.1038/s42003-022-03168-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 21

Abstract

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A Boolean network explorer (BoNE) computational algorithm was used to identify a dual agonist of the nuclear receptors PPARα and PPARγ that may be therapeutic in treating inflammatory bowel disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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