Nature Communications (Jan 2021)

Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging

  • Van Phuc Nguyen,
  • Wei Qian,
  • Yanxiu Li,
  • Bing Liu,
  • Michael Aaberg,
  • Jessica Henry,
  • Wei Zhang,
  • Xueding Wang,
  • Yannis M. Paulus

DOI
https://doi.org/10.1038/s41467-020-20276-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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This manuscript presents ultrapure chain-like gold nanoparticle clusters with red shifted absorption and shows their potential for in vivo imaging in living rabbits. The nanoparticles demonstrate a 17-fold increase in photoacoustic microscopy signal and 176% increase in optical coherence tomography signal.