Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging

Van Phuc Nguyen; Wei Qian; Yanxiu Li; Bing Liu; Michael Aaberg; Jessica Henry; Wei Zhang; Xueding Wang; Yannis M. Paulus

doi:10.1038/s41467-020-20276-z

Nature Communications (Jan 2021)

Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging

Van Phuc Nguyen,
Wei Qian,
Yanxiu Li,
Bing Liu,
Michael Aaberg,
Jessica Henry,
Wei Zhang,
Xueding Wang,
Yannis M. Paulus

Affiliations

Van Phuc Nguyen: Department of Ophthalmology and Visual Sciences, University of Michigan
Wei Qian: IMRA America, Inc.
Yanxiu Li: Department of Ophthalmology and Visual Sciences, University of Michigan
Bing Liu: IMRA America, Inc.
Michael Aaberg: Department of Ophthalmology and Visual Sciences, University of Michigan
Jessica Henry: Department of Ophthalmology and Visual Sciences, University of Michigan
Wei Zhang: Department of Biomedical Engineering, University of Michigan
Xueding Wang: Department of Biomedical Engineering, University of Michigan
Yannis M. Paulus: Department of Ophthalmology and Visual Sciences, University of Michigan

DOI: https://doi.org/10.1038/s41467-020-20276-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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This manuscript presents ultrapure chain-like gold nanoparticle clusters with red shifted absorption and shows their potential for in vivo imaging in living rabbits. The nanoparticles demonstrate a 17-fold increase in photoacoustic microscopy signal and 176% increase in optical coherence tomography signal.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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