The paper presents the regional features of urban mortality in Russia by the example of 175 cities with a population of more than 100000. The spatial features of mortality due to main causes of death are defined for male and female separately. The more favorable situation is defined for urban population than rural for all-cause mortality. The exception is industrial cities, where the mortality rate can reach high values. The results of a correlation analysis of the impact of environmental factors on the urban mortality are presented.