Nature Communications (Aug 2020)

Isobutanol production freed from biological limits using synthetic biochemistry

  • Saken Sherkhanov,
  • Tyler P. Korman,
  • Sum Chan,
  • Salem Faham,
  • Hongjiang Liu,
  • Michael R. Sawaya,
  • Wan-Ting Hsu,
  • Ellee Vikram,
  • Tiffany Cheng,
  • James U. Bowie

DOI
https://doi.org/10.1038/s41467-020-18124-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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A cell free or synthetic biochemistry approach offers a way to circumvent the many constraints of living cells. Here, the authors demonstrate, via enzyme and process enhancements, the production of isobutanol with the metrics exceeding highly developed ethanol fermentation.