Communications Biology (Mar 2021)

A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure

  • Fatemeh Khodadadei,
  • Allen P. Liu,
  • Carolyn A. Harris

DOI
https://doi.org/10.1038/s42003-021-01888-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Khodadadei et al. investigate the mechanisms underlying cerebral shunt failure using a microfluidic chip to simulate shear forces in the shunt. Employing total internal reflection fluorescence imaging, their findings indicate that astrocyte interleukin-6 cytokine secretions increase under higher shunt shear stresses, informing future shunt design and potential drug therapies to reduce shunt failure in patients.